近期翻译的三个帖子，版主认为有用的话，请将此贴汇总标记一下。
本帖最后由 moveon 于 2011-1-8 15:40 编辑窗口期的定义：http://www.120x.net/thread-82745-1-1.html
4代准确度：http://www.120x.net/thread-82734-1-1.html
恐症状，想做病毒载量的问题：http://www.120x.net/thread-82698-1-2.html
关于第四代试剂的原理，第四代试剂加入了P24抗原，合并抗体一同检测。可以相对缩短窗口期到4周，准确度非常高。接近99.99%
P24抗原是什么？
3. P-24 antigen is a core protein of an HIV viral particle that surrounds the viral RNA. P-24 antigen production is kicked into gear when HIV is replicating. So the more HIV replication, the more P-24 antigen produced. Hence, this is a fairly good marker for acute HIV infection when there's an amazing amount of HIV replication taking place. (HIV can self-replicate to the tune of 10 billion times per day!) The P-24 antigen (protein) begins to appear in the blood within a few days of the high viral replication process. However, it then disappears within a couple of weeks as "P-24 antibodies" begin to develop as part of the body's immune defense. Today, P-24 antigen tests are sometimes used as an alternative to HIV RNA tests to detect acute HIV infection, due to their reduced cost. It is also used in fourth generation HIV screening tests that combine a third generation format ("antigen-sandwich" format) for anti-HIV antibody detection with the ability to simultaneously detect HIV P-24 antigen using ELISA techniques. These combination assays allow for earlier viral detection in those with primary HIV infection. This may be more information than you wanted to know, but hey, you asked!
http://www.thebody.com/Forums/AIDS/SafeSex/Archive/Symptoms/Q181902.html
P24抗原是一种环绕在病毒RNA周围的核心蛋白颗粒。当HIV开始复制时，就会产生P24抗原。病毒复制的越多，就会有越多的P24。因此，在感染初期检测P24抗原是一个非常准确的方法。随着病毒的告诉复制，在几天后P24就会出现在血液当中，但是接下来P24会在几周之后消失。（被免疫系统产生的抵抗机制消灭掉）
因此，P24不是也不可能一直存在在血液中，P24抗原加入的检测机制可以相对缩短窗口期，用于早期检测。但一旦超过4-6周左右的时间，P24在体内会逐渐消失。因此6周后4代的意义就等同于3代了。
仅代表www.medhelp.org..www.thebody.com上的医生的观点（还有部分我的及我咨询过的CDC医生的）。只是希望大家把国内外的知识都综合下，更好的学习。
页:
[1]
