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发表于 2011-3-31 14:32
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八院的医生看的参考资料是这本书!
美国《HIV2007版》关于窗口期的定义(2009-04-06 08:41:02)
The diagnosis of an HIV infection is normally made indirectly, i.e. through the demonstration of virus-specific antibodies (Gürtler 1996). These markers of a humoral immune response against the agent are found in virtually 100% of HIVinfected individuals. Their presence equals the diagnosis of chronic active HIV infection.Cases in which infected individuals persistently fail to have detectable antibodies against HIV are exceedingly rare and so far play hardly any role in clinical practice (Connick 2005, Kassutto 2005).HIV感染靠的是特异性抗体检测阳性(不是急性期症状),抗体检测的可靠性100%,目前没有发现感染HIV而检测不到抗体的。(总怀疑自己感染HIV而抗体始终阴性的患者,建议就诊心理科)
After HIV infection has taken place, it takes several weeks before antibodies become detectable. This phenomenon is called "diagnostic window" and is determined by the time period the body requires to produce detectable levels of antibodies (Busch 1997). HIV感染后人体产生可以检测到的抗体的时间,称窗口期。The switch from antibody-negative to antibody-positive is called "seroconversion". 从抗体阴性转成抗体阳性称血清转化。The screening tests currently used are able to recognize an HIV infection six weeks after primary infection in about 80 % and after the 12th week in almost 100 % of cases; 目前使用的初筛实验感染后6周时的检出率为80%,12周时几乎100%。only in very rare cases is an infection recognized only after six months. 只有极个别的案例到6个月。4th generation screening assays attempt to shorten the duration of the "diagnosticwindow" by detecting HIV antibodies and HIV p24 antigen simultaneously (Gürtler 1998, Ly 2001). Although these 4th generation tests become reactive earlier in the course of an acute primary nfection, a second "diagnostic window" phase may occur later on due to methodological reasons, during which the tests may again become non-reactive (Meier 2001).4代酶联检测加入抗原检测(同时检测抗体和p24抗原),可以缩短窗口期,但是由于抗原检测的第二个窗口期(抗原可以早期出现,然后消退,然后再次出现),目前的窗口期还是12周。
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