我把最近国外艾滋病论坛询问和答复翻译给大家，大家有恐看看，不只我们在恐

kamino

提问者：HIV questions
by ahad111, May 20, 2010 05:22AM
Tags: HIV, question, antibodies
1) I had a cmia (chemiluminiscent Microparticle Immunoassay ) test for the detection of HIV antibodies to HIV 1 and 2 and p24 antigen.Is this a fourth generation test and what is the window period for this specific test ?
2)The p24 antigen remains in the blood stream untill antibodies are produced right ? So even if i am in the window period and antibodies have not been produced the cmia test would detect the p24 antigen and test reactive right ?
3)I tested negative at 32 weeks post my last exposure 4 times.Twice using the immunochromatography is this conclusive and has it ever happened a normal individual not on chemo or any drug test positive after testing negative at 7.5-8 months ?
4)I also had  a cd4 and cd8 count done.My cd4 count was 522 and cd8 count was 416 hence my cd4/cd8 ratio 1.25 is this normal for a HIV Negative person ?(took the test in the afternoon,was a bit stressed.)


医生：Hello,
Thank you very much for your post and welcome to our forum.  I am going to try to answer your questions one by one here below:
1) I had a cmia (chemiluminiscent Microparticle Immunoassay ) test for the detection of HIV antibodies to HIV 1 and 2 and p24 antigen.Is this a fourth generation test and what is the window period for this specific test ?
YES, IT IS A 4TH GENERATION TEST, ALSO CALLED DUO OR COMBO HIV TEST.
2)The p24 antigen remains in the blood stream untill antibodies are produced right ? So even if i am in the window period and antibodies have not been produced the cmia test would detect the p24 antigen and test reactive right ?
p24 ANTIGEN IS DETECTABLE ALREADY AFTER TWO WEEKS FOLLOWING INFECTION, REACHING VERY HIGH LEVELS AT 4-6 WEEKS AND THEN GRADUALLY DROPPING AS ANTIBODY LEVELS RISE.  NORMALLY IF SOMEONE HAD BEEN INFECTED, YOU WOULD EITHER DETECT THE p24 ANTIGEN, THE ANTIBODIES OR BOTH. SO THE ANSWER TO YOUR QUESTION IS YES.
3)I tested negative at 32 weeks post my last exposure 4 times.Twice using the immunochromatography is this conclusive and has it ever happened a normal individual not on chemo or any drug test positive after testing negative at 7.5-8 months ?
IT IS CONCLUSIVE AND IT HAS NEVER HAPPENED UNDER NORMAL CIRCUMSTANCES.
4)I also had  a cd4 and cd8 count done.My cd4 count was 522 and cd8 count was 416 hence my cd4/cd8 ratio 1.25 is this normal for a HIV Negative person ?(took the test in the afternoon,was a bit stressed.)
IT IS NORMAL.  YOU ARE HIV NEGATIVE.

BEST WISHES,
DR JOSE

kamino

1）我做了一个cmia测试看是否有HIV抗体1和2和p24抗原，这个4代测试需要的窗口期是多久。
（2）主要是问了P24要多久才可以测试出来。
（3）主要说了他32周之间取测试了4次，并且询问是不是经过化疗（注意这个）和吸毒的需要7.5-8周
（4）我还没搞了一个cd4和cd8，我的cd4细胞是522，cd8是416 cd4/cd8是1.25，这个是不是一个HIV怀疑者。

kamino

医生的回答：
（1）是的,这是一个第4代测试,也称为或组合艾滋病毒检测。
（2）p24抗原检测后已经两周后,达到很高水平，感染在4-6周,然后逐渐下降，并且抗体水平升高。如果有人感染通常,可以探测到p24抗原抗体,或两者兼而有之，所以你问题的答案是肯定的。（大家注意恐6周的兄弟伙，还恐吗，虽然是4代，但是3代现在测试剂也不错的，4周很保守了，别人2代2周就可以查抗原了，看到是2周抗原就最高水平）
（3）它是决定性的,它从来不会发生在正常情况下。（意思说化疗的和吸毒的才被列为免于能力不好者，什么常常感冒的哥们以后别问窗口期会不会延后）
（4）IT IS NORMAL.  YOU ARE HIV NEGATIVE这个很正常，你是一个 阴

kamino

这个是关于窗口期的，大家可以看看